Through the lens of light sheet, knee innervation shines
Frank C. Ko, Alejandro J. Almarza, Kyle D. Allen, Anne-Marie Malfait, Rachel E. Miller
Osteoarthritis Cartilage. 2026 Sept
Gut microbiota depletion alters functional recovery and bone healing following fracture in mice
Parker Kooima, Daniel A Oesterle, Yassna Hematti, David M Kay, Kyle McFarlane, Joseph L Roberts
Bone. 2026 Aug:209:117907
Aging-associated increase of GATA4 levels in articular cartilage is linked to impaired regenerative capacity of chondrocytes and osteoarthritis
Meagan J Makarczyk, Yiqian Zhang, Alyssa Aguglia, Olivia Bartholomew, Sophie Hines, Kate Li, Suyash Sinkar, Silvia Liu, Craig Duvall, Hang Lin
eLife. 2026 Aug
Evaluation of physical function in patients with inflammatory myopathies using the health assessment questionnaire-II (HAQ-II)
Sung-Ki Lee, Kristin Wipfler, Ethan Ritz, Burcu Aydemir, Kaleb Michaud, Didem Saygin
Semin Arthritis Rheum. 2026 Aug:79:153015
Leptin drives osteoarthritis pain through sensory neuron reprogramming independent of cartilage signaling
Hope D. Welhaven, Elise K. Truchan, Kristin L. Lenz, Bethany A. Andoko, Michael R. Mazzucco, Reyna E. Villa, Arin K. Oestreich, Bo Zhang, Dana E. Orange, Joseph B. Lesnak, Theodore J. Price, Farshid Guilak, Kelsey H. Collins
BioRxiv. 2026 Jun
Understanding online discussions related to pain among patients living with myositis
Peter Kerkhof, Mohammad Radaideh, Latika Gupta, Didem Saygin
Rheumatology International. 2026 May
Synovial transcriptional clusters link cartilage degeneration to cell-type-specific gene expression in knee osteoarthritis
Michael R. Mazzucco, Bella Mehta, Jenelys Ruiz-Ortiz, Caryn Hale, Fuadur Omi, Purva Singh, Ruoxi Yuan, Samantha Lessard, Eun Kyung Song, Mengrui Zhang, Shady Younis, William H. Robinson, Daniel Ramirez, Edward DiCarlo, Wei Wang, Thomas Carroll, Jose Rodriguez, Peter Sculco, Xiaoshun Li, YiYuan Wu, Robert B. Darnell, Martin Lotz, Rachel E. Miller, Tristan Maerz, Anne-Marie Malfait, Accelerating Medicines Partnership: RA/SLE Network (AMP RA/SLE), The RE-JOIN Investigators, Miguel Otero, Dana E. Orange
Annals of the Rheumatic Diseases. 2026 In Press
Identification of Adult Patients With Dermatomyositis Using Real-World Data Sources
Benjamin Martin, Will Kelly, Hannah Morgan-Cooper, Thomas Falconer, Elizabeth Park, Priya Desai, David Fiorentino, Lorinda Chung, Sean Yen, Zachary Wang, Didem Saygin, Michael George, Gowtham A Rao, Joel Swerdel, Azza Shoaibi, Christopher A Mecoli
Arthritis Care Res. 2026 Mar
Integrative Single-Cell RNA Sequencing and Spatial Transcriptomics Uncover Distinct Fibroblast–Macrophage Crosstalk in Human Hip Synovium Between Patients With Femoroacetabular Impingement and Osteoarthritis
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia-Lung Wu
Arthritis Rheumatol. 2026 Jan
Prevalence of Pain and Factors Associated With Pain in Patients With Idiopathic Inflammatory Myopathies
Didem Saygin, Anne-Marie Malfait, Ethan M Ritz, Kristin Wipfler, Kaleb Michaud, Yvonne C Lee
Arthritis Care Res. 2026 Jan
FM-dye inhibition of Piezo2 relieves mechanically evoked pain in mouse models of acute inflammatory and osteoarthritic knee pain
Natalie S Adamczyk, Shingo Ishihara, Alia M Obeidat, Daniel B Hoffman, Brian T David, Dongjun Ren, Richard J Miller, Anne-Marie Malfait, Rachel E Miller
Br J Pharmacol. 2026 Jan
Probiotic Supplementation Enhances Functional Recovery and Modulates the Serum Metabolome in Mice
Joseph L Roberts, Parker Kooima, Jarred Kaiser, Jinhua Chi, Haiwei Gu, Hicham Drissi
J Orthop Res. 2025 Dec
Regulation of Chondrocyte Metabolism and Osteoarthritis Development by Sirt5 Through Protein Lysine Malonylation
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C Martino, Anna E Miller, Craig R G Willis, Shivakumar R Veerabhadraiah, Joanna Bons, Jacob P Rose, Birgit Schilling, Michael J Jurynec, Shouan Zhu
Arthritis Rheumatol. 2025 Sept
Mechanisms of joint pain: Five short lessons from osteoarthritis
Anne-Marie Malfait.
Semin Arthritis Rheum. 2025 Jun:72S:152690
Potential sources of pain in symptomatic degenerative meniscal tear: A narrative review
Love Tsai, Elizabeth Matzkin, Morgan H Jones, Rachel E Miller, Jeffrey N Katz
Osteoarthr Cartil Open. 2025 April
Clearing-enabled light sheet microscopy as a novel method for three-dimensional mapping of the sensory innervation of the mouse knee
Frank C Ko, Spencer Fullam, Hoomin Lee, Kelly Chan, Shingo Ishihara, Natalie S Adamczyk, Alia M Obeidat, Sarah Soorya, Richard J Miller, Anne-Marie Malfait, Rachel E Miller
J Orthop Res. 2025 March
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
Kelsey H. Collins, Kristin L. Lenz, Hope D. Welhaven, Erica Ely, Luke E. Springer, Sophie Paradi, Ruhang Tang, Lauryn Braxton, Antonina Akk, Huimin Yan, Bo Zhang, Xiaobo Wu, John P. Atkinson, Arin K. Oestreich, Ron K. June, Christine T. N. Pham, and Farshid Guilak.
Sci. Adv. 11, eadt5915 (2025).
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage
Terese Geraghty, Shingo Ishihara, Alia M Obeidat, Natalie S Adamczyk, Rahel S Hunter, Jun Li, Lai Wang, Hoomin Lee, Frank C Ko, Anne-Marie Malfait, Rachel E Miller
Arthritis Res Ther. 2024 Dec
A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis
Alia M Obeidat, Sung Yeon Kim, Kevin G Burt, Baofeng Hu, Jun Li, Shingo Ishihara, Rui Xiao, Rachel E Miller, Christopher Little, Anne-Marie Malfait, Carla R Scanzello
Osteoarthritis Cartilage. 2024 Oct
Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
Bergman RF, Lammlin L, Junginger L, Farrell E, Goldman S, Darcy R, Rasner C, Obeidat AM, Malfait AM, Miller RE, Maerz T.
Osteoarthritis Cartilage. 2024 Jul
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Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models
Alia M Obeidat, Shingo Ishihara, Jun Li, Natalie S Adamczyk, Lindsey Lammlin, Lucas Junginger, Tristan Maerz, Richard J Miller, Rachel E Miller, Anne-Marie Malfait
Front Neuroanat. 2024 Jul
Charge-Reversed Exosomes for Targeted Gene Delivery to Cartilage for Osteoarthritis Treatment
C. Zhang, T.V. Pathrikar, HM Baby, J. Li, H. Zhang, A. Selvadoss, A. Ovchinnikova, A. Ionescu, S. Chubinskaya, RE Miller, A.G. Bajpayee.
Small Methods. 2024 April
Reduced Capsaicin-Induced Mechanical Allodynia and Neuronal Responses in the DRG in the Presence of Ptpn6 Overexpression
Vroman R, Ishihara S, Fullam S, Wood MJ, Adamczyk NS, Lomeli N, Malfait F, Malfait AM, Miller RE, Markovics A.
Mol Pain. 2024 May 16.
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The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy
George DS, Jayaraj ND, Pacifico P, Ren D, Sriram N, Miller RE, Malfait AM, Miller RJ, Menichella DM.
Pain. 2024 May 1;165(5):1154-1168.
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Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis
Bai Z, Bartelo N, Aslam M, Murphy EA, Hale CR, Blachere NE, Parveen S, Spolaore E, DiCarlo E, Gravallese EM, Smith MH; Accelerating Medicines Partnership RA/SLE Network; Frank MO, Jiang CS, Zhang H, Pyrgaki C, Lewis MJ, Sikandar S, Pitzalis C, Lesnak JB, Mazhar K, Price TJ, Malfait AM, Miller RE, Zhang F, Goodman S, Darnell RB, Wang F, Orange DE.
Sci Transl Med. 2024 Apr 10;16(742):eadk3506.
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Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model.
Lai A, Iliff D, Zaheer K, Gansau J, Laudier DM, Zachariou V, Iatridis JC.
Int J Mol Sci. 2024 Feb 1, 25(3):1762
P30 Funded Publication
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Diverse Response to Local Pharmacological Blockade of Sirt1 Cleavage in Age-Induced versus Trauma-Induced Osteoarthritis Female Mice.
Maatuf YH, Marco M, Unger-Gelaman S, Farhart E, Zobrab A, Roy A, Kumar A, Carmon I, Reich E, Dvir-Ginzverg M.
Biomolecules 2024, 14(1), 81
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Sensory profiling in classical Ehlers-Danlos syndrome: a case-control study revealing pain characteristics, somatosensory changes, and impaired pain modulation
Colman M, Syx D, de Wandele I, Rombaut L, Wilie D, Malfait Z, Meeus M, Malfait AM, Van Oosterwijck J, Malfait F.
medRxiv [Preprint]. 2023 Feb 26, Update in: J Pain. 2023 Nov;24(11):2063-2078
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Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours.
Courties A, Olmer M, Myers K, Ordoukhanian P, Head SR, Natarajan P, Berenbaum F, Sellam J, Lotz MK.
Ann Rheum Dis. 2023
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Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.
Obeidat AM, Wood MJ, Adamczyk NS, Ishihara S, Li J, Wang L, Ren D, Bennett DA, Miller RJ, Malfait AM, Miller RE.
Nat Commun. 2023 Apr 29
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Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain.
Lai Wang, Shingo Ishihara, Jun Li, Rachel E Miller, Anne-Marie Malfait.
Arthritis Res Ther 25, 63 (2023)
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Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice.
Geraghty, T., Obeidat, A.M., Ishihara, S., Wood, M.J., Li, J., Lopes, E.B.P., Scanzello, C.R., Griffin, T.M., Malfait, A.-M. and Miller, R.E. Arthritis and Rheumatology 2023
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