Nobel laureate: I owe America my success. Today, its scientific future is in danger
"As a US citizen, I believe it’s my duty to advocate for investment in science, which has long been one of the keys to of our national success," writes Dr. Ardem Patapoutian. More…
New Publication | Featured in Science Advances - Journal Club on May 12
Obesity is a risk factor for osteoarthritis (OA), and leptin is among the adipokines implicated in obesity-induced OA. However, the specific role of leptin in OA severity and pain is not known. Using lipodystrophic (LD) mice, we show that fat-secreted factors are required for knee OA development, implicating a fat-cartilage cross-talk. More…
Seminar Talk | Dr. Yvonne Lee from Northwestern University - April 7, 2025
Join us for our next C-COMP seminar More…
BORS-BJR fellows visit C-COMP
Five orthopaedic researchers selected by the British Orthopaedic Research Society (BORS) and Bone & Joint Research (BJR) visit C-COMP as part of the 2025 fellowship program. More…
Seminar Talk | Dr. Zsuzsa Jenei-Lanzl from Goethe University - February 24, 2025
Join us for the next C-COMP seminar, "The vicious circle of chronic stress, inflammation and pain in osteoarthritis" More…
C-COMP Journal Club Presents Dr. Henning Bliddal from Copenhagen University - January 13, 2025
Featured in New England Journal of Medicine: "Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis". More…
New Publication | Featured in the Journal of Orthopaedic Research - November 15, 2024
A major barrier that hampers our understanding of the precise anatomic distribution of pain sensing nerves in and around the joint is the limited view obtained from traditional two dimensional (D) histological approaches. Therefore, our objective was to develop a workflow that allows examination of the innervation of the intact mouse knee joint in 3D by employing clearing-enabled light sheet microscopy. More…
New Publication | Featured in Frontiers - July 14, 2024
Knee joints are densely innervated by nociceptors. In human knees and rodent models, sprouting of nociceptors has been reported in late-stage osteoarthritis (OA). Here, we sought to describe progressive nociceptor remodeling in early and late-stage OA, using four distinct experimental mouse models. More…
Seminar Talk | Dr. David Hunter from the University of Sydney - November 14, 2024
C-COMP Seminar: “Assessment of pain in knee osteoarthritis” More…
COMPositions Guest Post - Tulsa Johnson
Female Hysteria and Healthcare: How Does the History of Female Hysteria Affect Women’s Healthcare Today? When I was in high school, I read a short story by Charlotte Perkins Stetson called “The Yellow Wallpaper”. In reading this story I felt camaraderie with the main character’s experiences. More…
Seminar Talk | Dr. Richard Miller from Northwestern University - October 21, 2024
Join us for our upcoming C-COMP seminar featuring Dr. Richard J. Miller on October 21, 2024, at 3:00 pm CST! More…
2024 RFA for Pilot Grants Released
C-COMP Pilot Grant Announcement: Deadline October 1. More…
New Publication | Featured in Molecular Pain - May 16, 2024
Reduced Capsaicin-Induced Mechanical Allodynia and Neuronal Responses in the DRG in the Presence of Ptpn6 Overexpression More…
New Publication | Featured in PAIN - May 2024
The Mas-related G protein–coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy More…
New Publication | Featured in Science Translational Medicine - April 10, 2024
Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis More…
New Publication | Featured in International Journal of Molecular Sciences- February 1, 2024
Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord—An In Vivo Rat Discogenic Pain Model More…
The Role of Women in the History of the Animal Rights Movement
"Once you get to the 16th century, there was Montaigne who wrote eloquently about the reasons why we should respect the intelligence and feelings of animals. Then in the 17th century there was Margaret Cavendish, the first women to write about these topics, followed by others in the 18th century. Suddenly, in the 19th century, there were a huge number of women involved in the animal rights movement; actually, I think it was mostly women! Why was this?" More…
New Publication | Featured in Biomolecules - January 8, 2024
Diverse Response to Local Pharmacological Blockade of Sirt1 Cleavage in Age-Induced versus Trauma-Induced Osteoarthritis Female Mice. More…
C-COMP Seminar | Ewan St. John Smith, MPharmacol, PhD on January 8, 2024
P30 JOINT Seminar Presentation More…
Seminar Talk | Philip Band, PhD on November 20, 2023
C-COMP seminar Monday, Nov 20, 2023, at Northwestern University. More…
2023 Inaugural Symposium | December 4, 2023
View the 2023 Meeting Agenda. More…
C-COMP Journal Club - September 25, 2023
Join us for our upcoming C-COMP Journal Club presentation featuring Dr. Alice Courties and Dr. Paul Peter Tak on September 25, 2023, at 10:00 am CST! More…
“The study of omics in TwinsUK.” - Frances MK Williams, PhD, FRCP(E)
Upcoming T32/P30 JOINT Seminar - Monday, August 28, 2023. Contact us for details on how to attend! More…
2023 Pilot Grant Awardees Announced
The Chicago Center on Musculoskeletal Pain would like to announce this year's pilot grant recipients! More…
New Book Publication | Neurobiology Core Director - Richard J. Miller, PhD
The Rise and Fall of Animal Experimentation critically examines this assumption and asks whether it is true that animal-based research achieves its aims and, if so, how often this occurs and if there are alternatives to performing animal-based science. -Oxford University Press 2023 More…
2023 Pilot Grant Call - Closed
The 2023 Pilot Grant Call is closed as of June 13. More…
C-COMP Journal Club - May 22, 2023
Upcoming Journal Club. More…
NIH HEAL Initiative Funding Opportunities for the Development and Validation of Preclinical Models and Measures of Pain
NIH HEAL Initiative Funding Opportunities More…
New Publication - Nature Communications
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis. More…
Recent Publications by Members
Find articles published by members of the Chicago Center on Musculoskeletal Pain! More…
2023 RFA for Pilot Grants Released
C-COMP Pilot Grant Announcement: Deadline June 12. More…
Research Spotlights | NIH HEAL Initiative
Explore the projects helping to make a difference in the opioid crisis. More…
Robert Boyle and His Dogs
“Why, we can hardly call it a complaint, Miss Ruthyn. I look upon it he has been poisoned-he has had, you understand me, an overdose of opium; you know he takes opium habitually; he takes it in laudanum, he takes it in water, and most dangerous of all, he takes it solid, in lozenges. More…
RE-JOIN Award Alert
Re-Join Award Alert More…
2022 Pilot Grant Awardees Announced
We are very pleased to announce the first awardees of the C-COMP pilot grants. More…
2022 Pilot Grants Closed
Thank you to the 14 groups that submitted pilot grant applications this year - submissions are now closed for 2022. More…
2022 RFA for Pilot Grants
$25K for 1 year, focused on mechanisms underlying pain in musculoskeletal and rheumatic disease. Apply now, deadline July 15 2022. More…
Inaugural Seminar
April 25, 2022: 3-4 p.m. - Kelsey H. Collins, PhD - “Using Patient-Relevant Outcomes and Tissue Engineering Strategies to Study Fat-Cartilage Crosstalk” More…
Launching C-COMP
How do we know if something is alive? Probably the thing that would first strike us would be the presence or absence of some kind of coordinated movement. More…
WashU MSK Biology & Regeneration Symposium
The Wash U Centers of Musculoskeletal Research and Regenerative Medicine are hosting the 2nd Musculoskeletal Biology and Regeneration Meeting at the WUSM campus in St. Louis on May 5-6, 2022. More…
HEAL Initiative announces the Re-JOIN funding opportunity
The Helping to End Addiction Long-term (HEAL) Initiative announces the “Restoring Joint Health and Function to Reduce Pain (Re-JOIN)” funding opportunity. More…
Notice of Special Interest (NOSI): Promoting Pain Research Within the NIAMS Mission Areas
Notice of Special Interest (NOSI): Promoting Pain Research Within the NIAMS Mission Areas More…