May 8, 2023 Kaylan Smith-Frank

NIH HEAL Initiative Funding Opportunities for the Development and Validation of Preclinical Models and Measures of Pain

HEAL Initiative Notice of Special Interest (NOSI): Development and Validation of Pain-Related Models and Endpoints to Facilitate Non-Addictive Analgesic Discovery


The purpose of this Notice of Special Interest (NOSI) is to encourage the development, validation, and replication of animal models that recapitulate the phenotypic and physiologic characteristics of a defined pain type/indication and/or disease-associated pain condition and endpoints or outcome measures that can be used therein. The goal of this NOSI is to improve the translational application of animal models and/or outcome measures for the development of non-addictive analgesics. Ideally, models or measures proposed for this NOSI would have the potential to provide feasible and meaningful assessments of efficacy following therapeutic intervention that would be applicable in both preclinical and clinical settings. It utilizes PAR21-123, “Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery.”

Upcoming Receipt Dates: June 20, 2023; October 20, 2023

Program Contacts: Dr. Rebecca Roof (

   Dr. Julia Bachman (

HEAL Initiative: Development and Validation of Non-Rodent Mammalian Models of Pain (R01 Clinical Trial Not Allowed)


This funding opportunity announcement supports research to develop, characterize, and rigorously validate non-rodent mammalian models of pain, associated outcome measures and/or endpoints that will significantly advance translational research for effective pain management. These models are expected to recapitulate molecular, cellular, pathological, behavioral, and/or cognitive aspects of human pain disorders and conditions. Research supported under this NOFO is expected to provide well-validated models and measures that facilitate the development of non-opioid analgesic therapeutic interventions.

Upcoming Receipt Dates: July 6, 2023; November 7, 2023

Program Contact:  


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