C-COMP News

C-COMP Director and ORS Secretary Dr. Anne-Marie Malfait and Executive Director Brenda Osuch represented the Society at the congressional lunch briefing, Reducing Pain Across the Lifespan: Aging Well, Living Better, held on June 24, 2026, in Washington, D.C. More…

The Pilot Award Program is a new component of the NDRI's NIH-supported U42 program the Human Tissues and Organs for Research Resource (HTORR). More…

The C-COMP team was awarded an imaging grant this year by Miltenyi. More…

The video protocol describes how to measure knee hyperalgesia in mice. We show examples in mouse models of acute knee pain as well as in models of osteoarthritis (OA). More…

Collectively, these findings highlight the therapeutic potential of microbiota-targeted strategies as nonpharmacological interventions for improving functional recovery and reducing pain behavior following traumatic bone injury. More…

Our laboratory has studied mechanisms of OA pain using experimental models. Here, we briefly summarize five lessons learnt from these studies as well as from studies in subjects with OA, and how these findings might be applied to mechanistic studies in other painful RMDs. More…

"As a US citizen, I believe it’s my duty to advocate for investment in science, which has long been one of the keys to of our national success," writes Dr. Ardem Patapoutian. More…

Five orthopaedic researchers selected by the British Orthopaedic Research Society (BORS) and Bone & Joint Research (BJR) visit C-COMP as part of the 2025 fellowship program. More…

A major barrier that hampers our understanding of the precise anatomic distribution of pain sensing nerves in and around the joint is the limited view obtained from traditional two dimensional (D) histological approaches. Therefore, our objective was to develop a workflow that allows examination of the innervation of the intact mouse knee joint in 3D by employing clearing-enabled light sheet microscopy. More…

Knee joints are densely innervated by nociceptors. In human knees and rodent models, sprouting of nociceptors has been reported in late-stage osteoarthritis (OA). Here, we sought to describe progressive nociceptor remodeling in early and late-stage OA, using four distinct experimental mouse models. More…

C-COMP Pilot Grant Announcement: Deadline October 1. More…

Reduced Capsaicin-Induced Mechanical Allodynia and Neuronal Responses in the DRG in the Presence of Ptpn6 Overexpression More…

The Mas-related G protein–coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy More…

Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis More…

Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord—An In Vivo Rat Discogenic Pain Model More…

Diverse Response to Local Pharmacological Blockade of Sirt1 Cleavage in Age-Induced versus Trauma-Induced Osteoarthritis Female Mice. More…

The Chicago Center on Musculoskeletal Pain would like to announce this year's pilot grant recipients! More…

The Rise and Fall of Animal Experimentation critically examines this assumption and asks whether it is true that animal-based research achieves its aims and, if so, how often this occurs and if there are alternatives to performing animal-based science. -Oxford University Press 2023 More…

The 2023 Pilot Grant Call is closed as of June 13. More…

NIH HEAL Initiative Funding Opportunities More…

Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis. More…

Find articles published by members of the Chicago Center on Musculoskeletal Pain! More…

C-COMP Pilot Grant Announcement: Deadline June 12. More…

Explore the projects helping to make a difference in the opioid crisis. More…

Re-Join Award Alert More…

We are very pleased to announce the first awardees of the C-COMP pilot grants. More…

Thank you to the 14 groups that submitted pilot grant applications this year - submissions are now closed for 2022. More…

$25K for 1 year, focused on mechanisms underlying pain in musculoskeletal and rheumatic disease. Apply now, deadline July 15 2022. More…

The Wash U Centers of Musculoskeletal Research and Regenerative Medicine are hosting the 2nd Musculoskeletal Biology and Regeneration Meeting at the WUSM campus in St. Louis on May 5-6, 2022. More…

The Helping to End Addiction Long-term (HEAL) Initiative announces the “Restoring Joint Health and Function to Reduce Pain (Re-JOIN)” funding opportunity. More…

Notice of Special Interest (NOSI): Promoting Pain Research Within the NIAMS Mission Areas More…